Cholesterol metabolism in man.
نویسندگان
چکیده
It has been previously demonstrated that, in the rat, the major metabolic pathway of cholesterol involves the conversion of this molecule to bile acids (1, 2). These are excreted into bile and after repeated enterohepatic circulation (3) are finally eliminated in the feces, still in the form of bile acids. Over 80 per cent of the body's cholesterol was found to be metabolized in this manner (1, 2). In rat bile, the chief bile acid resulting from cholesterol metabolism has been identified specifically as the taurine conjugate of cholic acid (4-6). Since it is known that this reaction is not limited to the rat (7), there is some reason to expect that cholesterol is metabolized primarily by way of bile acids in man as well. Quantitative studies of the pathways of cholesterol breakdown in human beings have not, however, been previously published. Hellman and his co-workers have administered C'4-labeled cholesterol to patients and stated that this sterol is converted to cholic acid and to steroid hormones; however, no information on the quantitative importance of these compounds in cholesterol metabolism was reported (8). The purpose of the present study was to assess the quantitative significance of the various routes of cholesterol excretion and to determine the major end-products of cholesterol metabolism in man.
منابع مشابه
Adipose tissue and cholesterol metabolism.
Adipose tissue in man is a major site for cholesterol storage. In obesity over half of total body cholesterol may reside within this tissue; however, relatively little attention has been directed toward understanding the cholesterol metabolism and its relationship to whole body cholesterol homeostasis in this tissue. In this review the factors which influence cholesterol storage are discussed, ...
متن کاملStudies on the influence of dietary cholesterol on cholesterol metabolism in the isotopic steady state in man.
متن کامل
Dynamic aspects of cholesterol metabolism in different areas of the aorta and other tissues in man and their relationship to atherosclerosis.
متن کامل
Effects of inulin-type fructans on lipid metabolism in man and in animal models.
Studies in rodents show that inulin and oligofructose can reduce the plasma levels of cholesterol and triacylglycerols (TG). In addition, they can oppose TG accumulation in liver and have favourable effects on hepatic steatosis. The hypotriglyceridaemic effect is due to a reduction in hepatic re-esterification of fatty acids, but mainly in the expression and activity of liver lipogenesis, resul...
متن کاملThe Splenectomy Effects on Lipid Profile and Glucose Metabolism in the Major Thalassemia Patients
Background: Splenectomy is a common treatment for beta thalassemia. It not only eliminates many complications by reducing the need for blood transfusion, but also causes new complications that threaten the patientschr('39') health. The aim of this study was to determine if splenectomy could alter the lipid profile and glucose metabolism in beta thalassemia major patients. Methods: In this case-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of clinical investigation
دوره 34 9 شماره
صفحات -
تاریخ انتشار 1955